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Tau protein undergoes conformational changes and abnormal phosphorylation, which leads to its separation from microtubules, forming neurofibrillary tangles
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According to the statistics of the PharmaGo database, as of early February 2025, there were 179 GLP - 1 pipelines in the clinical stage globally, from 45 pharmaceutical companies, institutions and cooperation units
The placebo groups were pooled during analysis
Renal expression of rGLP-1 has not been fully characterized due to insufficient specificity and sensitivity of the antibodies used, although it have been non-uniformly detected in endothelial cells, macrophages, juxtaglomerular cells and proximal tubule in several animal models and human tissue
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