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As research advances and real-world experience accumulates, the integration of these agents into multifaceted, patient-centered care models holds promise for reshaping the future of weight management

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Crucially, the mitochondrial-mediated intrinsic and MAPK signaling pathways were involved in at least some of these positive effects

These findings should encourage regulatory agencies and clinicians to investigate further, given the heterogeneity of the human population. The European Medicines Agency (EMA) has already initiated a review of GLP1 agonists following reports of suicidal thoughts and other psychiatric adverse events