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Rothman KJ, Greenland S, Lash T (2008) Modern epidemiology
This has been tested most rigorously for semaglutide, says Dr
American Journal of Emergency Medicine, 12(4), 392-395
While GIP indeed acts as an incretin in healthy individuals, researchers found an important limitation in patients with type 2 diabetes, GIP loses most of its insulinotropic efficacy (the pancreatic cells become GIP-resistant) ( [32] )
Between these two, metformin is our first-line preference as it helps not only with antipsychotic-related weight gain but also with the metabolic side effects of antipsychotics (insulin resistance, fasting glucose, triglycerides, and hyperprolactinemia), earning it a recommendation from the APA for this purpose
They should also report medication exposure, renal function, diabetes status, diet, and time of day
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