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The critical implication of these findings is that OA should be reconceptualized, in a significant subset of patients, as a systemic metabolic disorder rather than a purely localized joint disease

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Reduced oxidative stress better regulation of reactive oxygen species (ROS) that can cause muscle fatigue and damage

Medication Timing and Interactions : Taking semaglutide at a consistent time each week and planning injection timing around social events or important activities can help patients manage side effects