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Due to their cost, however, coverage of GLP-1s for obesity treatment in Medicaid, ACA Marketplace plans, and most large employer firms remains limited, and GLP-1 coverage in Medicare for treatment of obesity is prohibited under current law

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To provide some insight into potential outcomes, let's consider the clinical study mentioned earlier, which evaluated nearly 2,000 overweight individuals from 16 countries after 68 weeks of taking 2.4mg of semaglutide [8]

It is important to note that regulatory bodies including the MHRA and EMA continue to monitor the safety profile of GLP-1 receptor agonists, including any potential psychiatric effects

Opposite results were also found in isolated adult rat cardiomyocytes that contraction was not be accelerated after treated with GLP-1 (107), accompanied with a decreased left ventricular contractility (108)