They will also take into consideration whether the patient is on other drugs that might be obesogenic, meaning causing weight gain, or if they are using an FDA-approved GLP-1 drug versus a compounded medication, which can have variable quality and unknown efficacy
Effects of liraglutide on the expression of local renin-angiotensin system, transforming growth factor-1 and collagen type III in pulmonary tissue of diabetic rats
However, covering this new class of medications may increase risk of premiums and claims with little known data around ROI
Some researchers question whether such extended holds make sense, since GLP-1RAs delay gastric emptying of solids by just 36 minutes [34]
Eli Lilly Press Release, 2025
Average weight gain from cessation to restarting the drug was 1.3%