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Firstly, the permeability of EBA increased after 24-h incubation with 3-PLG-ibu, and secondly, in inflammatory condition besides the 3-PLG-ibu-A-GSH the free ibuprofen treated group also significantly strengthened the integrity of the BBB model for the bigger transcellular marker molecule (Fig

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This structural modification increases melanocortin receptor (MC1R, MC3R, MC4R) agonist activity but also introduces conformational instability in aqueous solution

Int J Nephrol Renovasc Dis

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In contrast, berberine patches lack comparable evidence