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Western blot analysis of GPX4 expression in HC neutrophils (n = 3) when cultured with 20% HC serum or SLE serum supplemented with Cl-amidine (Cl, 100 M), APX-115 (APX) (pan-NADPH oxidase (NOX) inhibitor, 20 M), and GSK2795039 (GSK) (NOX2 inhibitor, 10 M)

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Nonetheless, the role of other upstream signaling pathways cannot be excluded

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