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Since then, the evolution of GLP-1 receptor agonists has progressed from initial short-duration agents like exenatide, to intermediate-duration formulations such as liraglutide, and further to advanced long-acting options including dulaglutide and semaglutide (The two products received approval for marketing in the U.S

Gojkovic S, Krezic I, Vrdoljak B, Malekinusic D, Barisic I, Petrovic A, et al

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Along with T2DM-induced hyperglycemia, cerebral blood flow (CBF) is obviously decreased on account of regulation of vasculature and vasoactive mediators, especially endothelium-derived nitric oxide (NO) (161)

Romeo S, Sanyal A, Valenti L (2020) Leveraging human genetics to identify potential new treatments for fatty liver disease