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While direct clinical trials specifically on active acne vulgaris are limited, the observed benefits are highly relevant to acne-prone skin: Improved Skin Density and Thickness: Clinical studies have shown GHK-Cus ability to increase skin density and thickness, which can contribute to a plumper appearance and potentially reduce the visibility of shallow scars

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The injection delivers the combination directly, and the format is one reason the compound is discussed alongside other clinic-administered or self-administered protocols