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High-dose IV glutathione promoted for skin whitening has drawn formal safety warnings from regulators the same review notes liver damage and severe allergic reactions among the concerns, and flags the absence of any standardized dosing as the core problem (Alzahrani et al., 2025)

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to lead to the expression of an alternative ERFE transcript, which suppresses hepcidin transcription and thereby provides an explanation for the increased iron load especially in these patients (36)

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