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Cardiovascular Considerations While Rybelsus has demonstrated cardiovascular benefit, patients with a history of heart disease should be aware that common side effects like nausea and diarrhea can lead to dehydration and electrolyte imbalances, potentially stressing the cardiovascular system
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However, persistent constipation remains her most frustrating side effect, even after the nausea subsided
Research and clinical investigation have produced one of the most extensively characterised profiles of any dual incretin research compound available in Europe: The SURPASS-2 trial documented Tirzepatides superiority over Semaglutide 1mg across HbA1c reduction and body weight loss providing the first head-to-head clinical validation that dual GIPR and GLP-1R co-agonism produces superior metabolic outcomes to the best-in-class selective GLP-1R monoagonist, establishing Tirzepatide as the new efficacy benchmark in incretin pharmacology and generating significant research interest across EU institutions in the mechanistic basis of dual incretin superiority
Data availability Uncropped western blot images are provided in Supplementary Fig
