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Thus it seems probable that the endocrine route becomes more prominent after extensive L-cell stimulation

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Background Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are an important advancement in treating obesity and type 2 diabetes as they increase insulin secretion after meals without triggering hypoglycemia, helping reduce appetite and consequently body weight

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Hayes MR, Schmidt HD

A third swears by magnesium citrate at bedtime