[76] [77] In a 72-week, phase IIIb open-label head-to-head trial of adults with obesity without diabetes, tirzepatide at the maximum tolerated dose produced greater mean weight loss than semaglutide and larger reductions in waist circumference, while gastrointestinal adverse events were the most common with both drugs
After at least 4 weeks, the dose can be increased to 1 mg once weekly, and if needed, to 2 mg once weekly
In large-scale studies, semaglutide (the active ingredient in Ozempic and Wegovy) led to an average placebo-corrected weight loss of about 12.4% at the 2.4 mg dose
Young CF et al
The most common include mild gastrointestinal issues like nausea, vomiting, or diarrhea, which usually decrease over time
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