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However, high-dose or prolonged unregulated use has been associated with liver stress in some cases

Liu Y, Wang S, Jin G, Gao K, Wang S, Zhang X, et al

A deficiency in Vitamin B2 can result in a sore throat, hypersensitivity to light, or migraine headaches

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Clinical treatment strategy for MTHFR-related psychiatric disorders As MTHFR plays a critical role in one-carbon metabolism, which is composed of folate, homocysteine, vitamin B12, and methylation of DNA, mutation of specific gene locus on MTHFR and correlative enzyme activity decline will affect various of physiological events as well as some pathology states, including psychiatric disorders

It can be administered either orally or intravenously