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Hollenberg, "Leptin Signaling Targets the Thyrotropin-Releasing Hormone Gene Promoter in Vivo," Endocrinology, vol

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MMP-9 expression is up-regulated by macrophages and is responsible for degrading extracellular matrix proteins including collagen, which results in thinning of the plaque's fibrous cap

Summary: In Phase 2 clinical trials, retatrutide was typically initiated at 2 mg once weekly via subcutaneous injection, with gradual dose escalation over several months under close medical supervision