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Call your provider if you notice: Thyroid warning signs: A lump in your neck, difficulty swallowing, or persistent hoarseness Gallbladder problems: Sharp pain in your upper right abdomen, especially after fatty meals Mood changes: Increased anxiety or persistent low mood Seek emergency care if you experience: Pancreatitis: Severe, persistent pain in your upper abdomen that radiates to your back, with or without vomiting Severe allergic reaction: Difficulty breathing, swelling of your face or throat, or a widespread rash after your injection Electrolyte imbalance: Sudden racing heartbeat caused by depletion of potassium and magnesium from frequent vomiting or diarrhea How long do tirzepatide side effects last