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Yet removing them does not repair dysregulated reward circuitry
While both drugs may have immediate health benefits, they are not short-term medications
In normal human physiology, GLP-1 and GIP are released by the gastrointestinal tract (enteroendocrine L cells in the small intestine and colon and enteroendocrine K cells respectively) in response to nutrient intake and have half-lives of 1 to 3 min [36]
This approach helps reduce side effects, improve adherence, and drastically lower pharmacy costs all without compromising outcomes
Common reasons include genetic resistance to GLP-1 signaling, non-adherence to dosing schedules, inadequate dietary changes, or underlying metabolic conditions that tirzepatide alone cannot address
Tinsley, G
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