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The GLP-1 Notch intracellular domain that is released by this cleavage transcriptionally regulates downstream targets, including the redundantly-acting genes lst-1 (lateral signaling target) and sygl-1 (synthetic Glp), to maintain a pool of GSCs within the PZ 13

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Prolonged dehydration can reduce kidney function and may increase the risk of acute kidney injury

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This monitoring serves both to detect any unexpected effects and to document individual response patterns