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Whether a given study design benefits from synchronising with that pulse, or deliberately offsetting it, depends on the readout being measured, because the timing affects whether the exogenous GH signal amplifies or dampens the endogenous pulse
While there is consensus about the presence of the MAS in neurons its expression level in astrocytes has been questioned (82)
Cell 149 (5), 10601072
Detailed information on the treatment is presented in the supporting file
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