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Some early work reported favorable effects on fat metabolism, while larger later trials did not produce the weight loss outcomes needed for approval as an obesity drug
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The gastrointestinal (GI) tract isnt just responsible for breaking down foodits central to immune function, hormonal signaling, nutrient absorption , and even brain health
It appeared to accelerate tendon-to-bone healing, reduce inflammation, and support gut lining repair
The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice
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