WARNINGS: Patients with early Leber's disease (hereditary optic nerve atrophy) who were treated with cyanocobalamin suffered severe and swift optic atrophy
References Heffernan MA, Jiang WJ, Thorburn AW, Ng FM
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Simultaneously, NNMT inhibition preserves SAM the primary methyl-donor for epigenetic histone and DNA methylation reactions which has been shown to influence gene expression programmes governing adipogenesis, lipid storage, and energy expenditure in adipose tissue models