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Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13
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With NNMT blocked, nicotinamide stays in the cell, NAD+ levels climb, and fat cells start burning more fuel instead of storing it
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