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Using gene expression data from the Broad Institute's measurement of 13,424 human genes, analysis revealed GHK increases gene expression in 59% of affected genes while suppressing expression in 41%

This decline results from increased consumption by CD38 (which rises with chronic inflammation), decreased synthesis via the NAMPT salvage pathway, and accumulated DNA damage driving PARP activation

Thus a 70 kg (150 lbs) person would be given around 110 g a day in hypothetical future research trials involving BPC-157 as an oral supplement

Why Managing Injection Discomfort Matters for Protocol Outcomes Injection site discomfort with GHK-Cu is a frequently cited reason for protocol discontinuation

PMID 22094366

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