To me, peptides represent perhaps the biggest challenge for anti-doping authorities today, and have also become a major consumer protection challenge
And the difference between the two groups came out at 1.6 points on a disease-activity score with a confidence interval that crossed zero [12]
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While the initial, weakly-desensitized AMPAR-like state for wild-type KAR is currently not available, it is most likely similar to the state represented by the recent mutant GluK2 structure (K676C and N802C) in the agonist-bound non-conducting state trapped by disulfide crosslinking across the LBD dimer interfaces (Zhou et al., 2025) (Figure 8A)