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Next, we performed NanoBiT complementation assays to determine the effect of the GLP-1R V229A substitution on receptor coupling to G proteins and -arrestins, assessing mini-G s , mini-G q , and -arrestin 2 recruitment dose response curves to WT versus V229A receptors after stimulation with a range of exendin-4 doses

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Originally developed for diabetes management, these therapies have demonstrated significant effectiveness in weight management and are reshaping conversations around obesity treatment, chronic disease prevention, and long-term healthcare costs

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It promotes muscle growth, recovery, and fat loss by stimulating cell growth and repair