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This fact is relevant as transgenic mice overexpressing IGFBP-2 were resistant to developing obesity when fed with high fat diet [174], suggesting that this molecule could have a direct effect on preadipocyte differentiation

For chronic tendinopathy where local repair has stalled, or for a patient with multiple tendon and joint issues simultaneously, the Wolverine Stack provides both the local activation signal and the systemic cell recruitment signal needed to restart the healing process

doi: 10.1210/en.2011-1443 19 HolstJJ

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doi: 10.1016/j.bbrep.2017.04.006 109 SinghRBansalRRathoreASGoelG

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