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Across registered trials, retatrutide has produced the largest weight reductions reported for an incretin-class compound roughly 24% at 12 mg over 48 weeks in phase 2 [1], extended to about 2829% over 6880 weeks in the phase 3 TRIUMPH topline [5], alongside lower HbA1c in type 2 diabetes and large falls in liver-fat content

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The copper ion is coordinated to the peptide through the nitrogen atoms of the glycine and histidine residues, giving the compound its distinctive blue color in crystalline form

This product has not been evaluated by the MHRA or FDA

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For other drugs, the arrival of generics has typically led to prices falling by 60-70%