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Science 315 , 17091712 (2007)
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These findings suggest that it is not the total body cysteine pool, but rather the free disulfide fraction that is associated with obesity, and with induction of PPARG and its target genes during adipogenesis (Elkafrawy et al
Lixisenatide, a structurally modified derivative of exendin-4, addresses some of these limitations by offering a longer half-life of approximately 3 h, thereby permitting once-daily dosing (Leon et al., 2017)
