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Glutathione is synthesized in the cytosol of each cell by the action of two enzymes in an elegantly regulated system that allows it to be maintained at different homeostatic levels in different tissue types, with the liver, given its detoxification role, having the highest amounts

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Patients with existing medical conditions might be at an increased risk for complications, which necessitates close monitoring of Glutathione levels in order to tailor the dosage according to individual tolerance and medical history

It would be highly desirable to conduct a trial studying absorption of glutathione from the human orobuccal mucosa comparing administration in the form of a lozenge versus an HPC film which theoretically offers more rapid absorption over a larger surface area

PMID: 17454637

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