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Moreover, we validated the relationship between GSH-regulated replication stress and JMF4073 sensitivity in a number of TKI-insensitive human CML blast-crisis cells, and present the evidence of the synthetic lethality by targeting glutathione biosynthesis with JMF4073 in these cells
Kosiborod M, Lam CSP, Kohsaka S, et al
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Actin Sequestration and Cytoskeletal Remodeling TB-500 functions as the primary actin-sequestering molecule in the blend, binding globular actin (G-actin) and regulating actin polymerization
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