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While peptide-based GLP-1R agonists such as semaglutide have transformed the treatment landscape, dual incretin receptor engagement further enhances metabolic outcomes
Semaglutide is a cutting-edge medication originally developed to treat type 2 diabetes
Curr Opin Environ Sci Health
The convergence of GLP-1 signaling with pathways of aginginsulin sensitivity, mitochondrial function, neuroinflammationsuggests these drugs may influence healthspan, not just body weight. (de Cabo & Mattson, 2019) For women entering their 50s and 60s, this convergence is especially powerful
These financial issues are the major driver of inequities in who can benefit from the GLP-1 medications