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binds GLP-1 receptors on pancreatic -cells (stimulating glucose-dependent insulin secretion), -cells (suppressing glucagon), gastrointestinal tract (slowing gastric emptying), and hypothalamic neurons (suppressing appetite and food intake via arcuate nucleus signaling)
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This enzyme acts as a sink for cellular energy precursors
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Apr 2022;10(4):227-234
Hsp60, Hsp70, and gp96 can enhance the expression of B7 and MHC-II on the surface of plasmacytoid dendritic cells (antigen presenting cells), stimulate dendritic cell maturation, migration to draining lymph nodes, and induce the secretion of chemokines by macrophages and plasmacytoid dendritic cells (DCs) (36)
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