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These studies were limited by the small number of patients and limited follow-up duration

Among 69,221 propensity-matched patients with IBD, those who had received a GLP-1 RA had a 5-year colorectal cancer incidence of 0.2% compared with 0.42% in non-GLP-1 RA users (OR, 0.49), corresponding to a 51% reduction in odds of developing colorectal cancer

Patients with UC produce large amounts of ROS and experience genetic material damage [80, 245], particularly in the rectum or sigmoid colon

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Albeit the FDA included the black box warning, but multiple studies, independent and meta analysis have come out that show zero increased risk for thyroid cancer of any kind associated with GLP1s

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