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Early signs may include: Sensory Nerves: Responsible for transmitting sensory information to the brain

Elderly patients tend to have a greater frequency of decreased hepatic, renal, or cardiac function, and also have concomitant disease or receiving other drug therapy

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For severe cases, a bigger dose might be given first, followed by smaller doses later

That level of transparency doesn't exist in supplement marketing, and it's why researchers increasingly trust community-aggregated data over vendor claims