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They act on the hunger and blood-sugar regulation pathways, making weight control easier and more stable

Semaglutide is a GLP-1 receptor agonist , which means it works with hormone pathways involved in appetite, fullness, digestion, and blood sugar response

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The article says limited direct studies examine the combination, and that the rationale rests on GLP-1 agonists modulating short-chain fatty acid production and gut barrier function