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Higher levels of Co(I)B12 are present in functional B2 deficiency, due to lack of activity of MTHFR, particularly with those mutations in the MTHFR protein , or in those with a diet low in folate, thereby making those individuals more susceptible to the action of Nitrous oxide

C., Martin, J

Taking Supplements

Side Effects : Mild diarrhoea, Nausea, Headache, Dizziness Injection site reactions (pain, redness, swelling) Itching or rash (rare) Severe allergic reactions (anaphylaxis) (rare) Caution: Not to be used in individuals with known hypersensitivity to Vitamin B12 or cobalt

This is the best route if you have underlying health conditions or want to discuss how B12 fits into your broader health plan

It counteracts both dopamine deficiency and excess, receptor blockade and overstimulation, neuronal destruction and vesicle depletion, all at the same dose range