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Studies in mice using several tissue-specific targeting strategies have confirmed that the elevation of circulating DPP4 in obesity is liver derived (2224), suggesting that DPP4 produced in the liver may primarily contribute to the progression of NAFLD (25)
Early studies also suggest potential benefit in men, with intranasal PT-141 improving erectile responses and increasing arousal measures in women [1]
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Therefore, conjugating CP to RGD's active sites may facilitate targeted delivery and enhance interference with tumor cell growth, although further experimental validation is needed to confirm these effects [170]
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