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Subsequently, the highly electrophilic RMs could react with nucleophilic groups contained in biomolecules, such as hepatic proteins, enzymes, and nucleic acids to form conjugates and/or adducts, leading to a sequence of toxicological consequences
doi: 10.4239/wjd.v10.i3.154 68 Ladeiras-LopesR.Fontes-CarvalhoR.BettencourtN.SampaioF.GamaV.Leite-MoreiraA
Even a single amino acid substitution can dramatically alter the peptide's properties and render it ineffective
Little is known, however, regarding the identity of the G protein(s) involved
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