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Studies in mice with CNS neuron-specific GLP-1R knockout showed that liraglutide failed to induce weight loss but still improved glucose levels, suggesting that brain GLP-1Rs are necessary for the weight-lowering effect of GLP-1RAs but not essential for their glucose-lowering effects (142)
Patients with type 2 diabetes or obesity who meet criteria for GLP-1 therapy may experience additional lipid benefits, particularly those with mixed dyslipidaemia, metabolic syndrome, or established cardiovascular disease
Meal spacing is good for fullness and cravings control
Those are meaningful wins
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Even if your family physician does not prescribe obesity medications personally, they can provide referrals to appropriate specialists and coordinate your overall care
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