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Third generation: multi-receptor agonists Tirzepatide targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors simultaneously, producing greater metabolic effects than GLP-1 alone: Mounjaro , once-weekly injection for type 2 diabetes (FDA-approved 2022)

Available from: European Commission

Additionally, adiponectin suppresses essential signaling pathways, including nuclear factor-kB (NF-kB) and p38, which are crucial for osteoclast formation [87]

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