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High-dose SSRIs like fluoxetine helped normalize neuropeptide abnormalities and supported the theory that serotonin dysregulation contributes to OCD symptoms

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FIGURE 1 At histopathological level, the main AD hallmarks are: (i) extracellular -amyloid (A) deposits, and (ii) intracellular neurofibrillary tangles (NFTs), containing bundles of paired helical filaments of the microtubule-associated hyperphosphorylated protein tau (Grundke-Iqbal et al., 1986

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