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e-mail: [email protected] Recibido para publicacin julio 12, 2005 Aceptado para publicacin enero 4, 2007 SUMMARY Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial growth modulation, erithropoyesis, vascularization and phagocitosis

Impaired antioxidant defense system of colonic tissue and cancer development in dextran sulfate sodium-induced colitis in mice

Muscle preservation: Because AOD 9604 targets adipose tissue specifically and does not suppress systemic anabolic signaling, researchers have hypothesized that it may allow for fat loss with less collateral impact on lean mass, though this has not been formally tested in head-to-head trials

Mast cell degranulation leads to the release and de novo synthesis of many mediators, including ROS

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This causes a host of metabolic problems, including insulin resistance