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Six months ago I was scrolling through forums at two in the morning, reading everything I could about Retatrutide and wondering if it was worth trying

These mechanisms are worth mentioning since if the results in this latest correspondence in the NEJM are indeed replicated, there is a large difference if these effects are occurring either a) Because pancreatic beta cells are dying less b) Because pancreatic beta cells are growing back c) Because pancreatic beta cells are not being targeted by the immune system anymore If replicated, I find a) and b) to be the most likely reasons

The coprimary endpoints were the percentage change in body weight and weight reduction of at least 5%

Energy and recovery benefits are often felt within 2-3 weeks

10.3389/fcimb.2017.00467 23 GrahamP

The distinction matters because vasodilation is temporary, requiring continuous application to maintain