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Most patients experience a minor pinch, but there is not a lasting ache that is usually felt with a vaccine shot (which is injected deeper into the muscle)

Key Benefits:

Clin J Am Soc Nephrol 16(6):908910 Kelly J, Su G, Zhang L, Qin X, Marshall S, Gonzlez-Ortiz A, Clase C, Campbell K, Xu H, Carrero J-J (2021) Modifiable lifestyle factors for primary prevention of CKD: a systematic review and meta-analysis

Participants received once-weekly subcutaneous retatrutide at 4 mg, 9 mg, or 12 mg, or placebo, for 80 weeks

Diabetes Care 43 , 28592869 (2020)

Seek urgent care for vomiting blood, black stools, or severe chest pain