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Holst J
Oral supplements may appear cheaper per unit but require significantly higher doses, which can offset the initial cost advantage
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For weight management, the proportion of individuals with overweight or obesity achieving 5% weight loss increases (approximately equivalent to 25 kg, depending on baseline weight), a threshold associated with improvements in blood pressure, blood lipids, functional capacity, and health-related quality of life 48
Several clinical trials have observed significant weight loss associated with the use of these drugs from 2.1 to 3.1 kg [46, 47]
Programs that cannot answer them clearly should be skipped
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