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Flavonoids can also interfere with the activation of transcription factors, such as nuclear factor-kappa B (NF-B) and activator protein-1 (AP-1) which regulate the expression of various pro-inflammatory genes (Yoon and Baek 2005)

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Genetic mutations that inhibit MC4R signaling lead to hyperphagia, decreased energy expenditure, and early-onset obesity, highlighting the receptor's fundamental importance in metabolic control

GLP-1 agonists are seen a lot in diabetes care, weight management and metabolic disorder therapies too

e , Liver weights after 12 weeks of HFD feeding (Control n = 12, Bmal1 -KO n = 12, Bmal1 -KO + NDI1 n = 7)

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