Thus, Htt reduces Cu 2+ to Cu 1+ , and copper promotes its aggregation, mediated by histidine residues ( Figure 6 schematizes the pathways that lead to symptoms of Huntingtons disease as a consequence of misfolded mutant Htt
Worgul 1976
Further research is needed to understand how the composition of intestinal microbiota influences the metabolic fate of ingested choline
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