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SARS-CoV-2 may activate TLR4 in the heart and lungs causing aberrant TLR4 signaling favoring the proinflammatory MyD88-dependent (canonical) pathway instead of the alternative TRIF/TRAM-dependent anti-inflammatory and interferon pathway (Aboudounya and Heads, 2021)

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2022 May 1;31(3):235-243

Some practitioners report that lower, more frequent doses (75-100mcg nightly) produce better stress-related benefits than higher intermittent doses