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M.JonkersD.VerbeekJ.et al (2020)
Instead of acting locally on the skin, its introduced systemically, usually in small doses injected under the skin
Skin Aging and Collagen Loss Skin aging involves several structural changes: reduced collagen synthesis increased collagen degradation decreased elastin integrity slower cellular turnover These processes contribute to wrinkles, skin laxity, and reduced resilience
Gray-Schopfer, V., Wellbrock, C
Biol Chem 376:651660
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